In the world of beauty and health, a new trend, a new device, or a new “miracle” cream emerges every day. However, some methods have maintained their popularity for decades, and even grown stronger with technological advancements. “Mesotherapy” is exactly such a treatment. Developed in 1952 by Dr. Michel Pistor and based on the principle of “small amounts, infrequently, and in the right place,” this method is a cornerstone of medical aesthetics today. In a world where expensive creams get stuck in the upper layer of the skin (epidermis) and orally administered vitamins are lost in the digestive system, mesotherapy is a logistical marvel that delivers the needed active ingredients directly to the address. So, how does this method, which we encounter in every field from facial rejuvenation to hair loss, cellulite treatment to localized weight loss, actually work? Why is it so popular despite being a needle-based procedure? In this comprehensive guide, we examine the biological mechanism of mesotherapy, its applications, and the changes it will create in your body in the finest detail.
The Logic of Mesotherapy: Why the “Middle Skin”?
Mesotherapy, which literally means “middle skin treatment” (Meso: Middle, Therapy: Treatment), targets the “mesoderm” layer of the skin. Why this particular layer? Because this is where collagen and elastin fibers, which provide the vitality, elasticity, and youthfulness of our skin, are produced, where blood circulation is maintained, and where stem cells are located. The molecules of the most expensive creams you apply are usually too large to reach this layer. A collagen pill you take orally is distributed throughout the body, and the amount that reaches your face or hair is only a trace.
Mesotherapy overcomes these obstacles by injecting vitamins, minerals, amino acids, enzymes, and hyaluronic acid directly to the source of the problem with very fine needles. This procedure offers a twofold benefit: Firstly, the injected pharmacological cocktail has a healing effect at the cellular level. Secondly, the micro-traumas created by the needle punctures trigger the body’s “healing mechanism.” The body sends growth factors to the area where the needle entered to repair it and accelerates blood flow. The result is tissue that is revitalized, nourished, and renewed from the inside out.
Areas of Use: Head to Toe Renewal
Mesotherapy is not a single treatment, but an application technique. Depending on the content of the “cocktail” used, it can be used for completely different purposes in different parts of the body. Here are the 3 main aspects of mesotherapy:
1. Facial Mesotherapy (Mesolift): The Skin’s Vitamin Depot
Skin that becomes dull, loses its moisture, is filled with fine wrinkles, and sags over time is “starved” skin. The Mesolift procedure restores the building blocks that the skin has lost. The mixture typically contains ingredients such as hyaluronic acid, which provides intense hydration, vitamin C, which brightens the skin, DMAE, which tightens, and salmon DNA, which renews cells. When applied regularly, the skin glows as if a light has been placed underneath it (Glow Effect). It is not only anti-aging; it is also applied with special formulas for acne scars, sun spots, and dark circles under the eyes.
2. Hair Mesotherapy: Awakening the Roots
For people experiencing hair loss or whose hair is weak and lifeless, mesotherapy is a life-giving water that nourishes the roots. When blood circulation in the scalp weakens, the roots cannot be adequately nourished and enter a dormant phase. With mesotherapy, vitamins (B group, Biotin), minerals (Zinc, Copper), and agents that increase blood circulation are directly delivered to the hair follicles. This process not only stops hair loss but also thickens existing hair strands and stimulates dormant roots, supporting new hair growth. It is also an indispensable support, especially for increasing the retention rate of transplanted roots after hair transplantation.
3. Body Mesotherapy: Cellulite and Localized Fat
Mesotherapy is used not only for beautification but also for shaping. In this method, also known as “lipolysis,” special enzymes (phosphatidylcholine, etc.) that break down the membrane of fat cells and allow the fat to be removed are injected into the problem areas. It is particularly effective on stubborn belly, hip, or chin fat that does not go away with diet and exercise. In addition, in cellulite treatment, cocktails that dissolve fibrous bands and regulate circulation significantly reduce the orange peel appearance.
What’s in a Mesotherapy Cocktail?
The success of mesotherapy depends on the quality of the mixture prepared or chosen by the doctor and its suitability to the patient’s needs. These cocktails are not standard; they are personalized. Here are the most frequently used superhero ingredients:
- Hyaluronic Acid: It retains 1000 times its own weight in water. It moisturizes and plumps the skin.
- Vitamins (A, B, C, E, K): Increases the skin’s antioxidant capacity, stimulates collagen production, and prevents the formation of blemishes.
- Amino Acids: They are the building blocks of proteins. They are essential for tissue repair and the formation of new cells.
- Minerals (Zinc, Selenium, Copper): Regulate cellular metabolism and fight free radicals.
- Coenzymes: Increase the energy production of cells, thereby accelerating the skin’s metabolism.
- Nucleic Acids: Stimulate cell renewal (e.g., Salmon DNA).
Mesotherapy vs. Other Methods: Comparison
With countless products and methods available on the market for skin and hair, why should you choose a needle-based procedure? The following table provides the answer to this question by comparing the effectiveness of mesotherapy with other methods:
| Features | Mesotherapy | Topical Creams / Serums | Oral Supplements (Pills) |
|---|---|---|---|
| Reaching the Target Area | 100% (Direct injection) | 5% – 10% (Blocks the skin barrier) | Low (Distributes throughout the body) |
| Speed of Effect | Fast (From the first session) | Slow (Takes months) (Usage) | Medium (Regular use required) |
| Risk of Side Effects | Minimal (Local bruising, etc.) | Allergic reactions may occur | Systemic side effects may occur |
| Persistence | Long-Term (In courses) | Effect ends when use is discontinued | Effect decreases when use is discontinued |
| Cost / Performance | High Efficiency | Low Efficiency / Ongoing Cost | Medium Efficiency |
Application Process: Does it Hurt?
Although the word “needle” scares many people, mesotherapy is an extremely comfortable procedure. The needles used in the application are as thin as a hair (30G or 32G). In addition, strong local anesthetic creams are applied to the skin before the procedure, which reduces the feeling of pain to almost zero.
Your doctor injects the medication under the skin using the “Nappage” (serial and superficial strokes) or “Micropapule” (creating small bubbles) technique. The procedure takes an average of 15-20 minutes for the face and 10-15 minutes for the hair. After the procedure, there may be slight redness on the face and tiny bumps at the needle entry points, but these disappear within a few hours. Rarely, small bruises may occur, which can be covered with makeup. In short, mesotherapy is a procedure that does not interrupt your social life, it falls into the category of “lunchtime aesthetics”.
Who is it suitable for? Who should not have it done?
Mesotherapy is suitable for almost everyone over the age of 18 who feels the need for skin or hair rejuvenation. However, it is contraindicated in some cases:
Pregnant and breastfeeding mothers, patients undergoing cancer treatment (except with doctor’s approval), those with blood clotting disorders, and those with active skin infections (herpes, etc.) should not undergo the procedure. In addition, caution should be exercised in people who are allergic to any of the substances used (for example, Salmon DNA is not performed in those with salmon allergy).
Conclusion: The Best Investment You Can Make in Yourself
Mesotherapy isn’t about applying a temporary mask to your skin or hair from the outside; it’s about nourishing it from within to unlock its potential. It’s one of the safest and most natural ways science offers to awaken tired skin, save thinning hair, or refine body contours. If you want to quench your skin’s “thirst” and give it the vitamin feast it deserves, mesotherapy might be the right key for you. Remember, healthy skin and hair are not only genetic but also the right care.
A New Beginning for Your Skin and Hair
Schedule an appointment now to discuss your personalized mesotherapy cocktails and treatment planning with our expert physicians.
