Izmir Under-Eye Mesotherapy
The area around the eyes (periorbital region) is the most expressive anatomical area of the human face and also the area that shows the earliest signs of aging. Described as the “window to the soul,” the eyes can lose their vitality over time due to fatigue, stress, genetic factors, and environmental effects (UV rays, screen use, etc.). Under-eye dark circles, fine wrinkles, and loss of elasticity can make a person look more tired or older than they are. At Izmir Private Demiderm Polyclinic, we approach the aesthetics of the eye area from a holistic and medical perspective. “Under-Eye Mesotherapy,” specifically developed for the delicate anatomy of the eye area, is a minimally invasive application that initiates a biological repair process by directly delivering the building blocks needed by this region to the target tissue. In this comprehensive guide, we will examine all the details, from the pathophysiology of under-eye problems to the mechanism of action of mesotherapy, from content analysis to application processes, in the light of scientific data.
What is Under-Eye Mesotherapy?
Under-eye mesotherapy is a procedure in which specially formulated cocktails are injected under the skin using micro-needles to improve the quality of the thin and delicate skin tissue around the eyes, alleviate dark circles, reduce fine lines, and regulate lymphatic drainage. Unlike classic mesotherapy, this procedure is performed with products that are suitable for the sensitivity of the eye area, have a lower molecular weight, and minimize the risk of edema.
Also known as “Periorbital Mesotherapy” in medical literature, this application targets the dermis layer of the skin. The aim is not only to provide temporary camouflage but also to trigger the skin’s own repair mechanisms (fibroblast activation, collagen synthesis, increased microcirculation) to provide long-term and structural improvement.
Mesotherapy Approach in Under-Eye Skin Thinning Problems
The eyelid skin has the thinnest skin structure in our body (approximately 0.5 mm). With age, the reduction of collagen and elastin fibers further thins the skin (“paper-like” appearance). This thinning skin makes the underlying vascular network and muscle tissue (orbicularis oculi) more visible, causing a purplish reflection. Mesotherapy aims to thicken the dermis layer and strengthen the skin barrier by providing intense moisture and building blocks to this area.
How Does Mesotherapy Work for Under-Eye Dark Circles?
Treatment for under-eye dark circles (Periorbital Hyperpigmentation) is planned according to the source of the problem. Mesotherapy works on dark circles through three main mechanisms:
- Vascular Regulation: A large portion of under-eye dark circles are caused by slowed blood circulation and the oxidation of blood outside the vessels (hemosiderin accumulation). Mesotherapy ingredients (Vitamin K, Ginkgo Biloba, etc.) reduce this shadowy appearance by accelerating microcirculation and strengthening blood vessel walls.
- Pigmentation Suppression: In cases of increased melanin due to genetics or sun exposure, agents such as Vitamin C, Glutathione, and Tranexamic acid in the mesotherapy cocktail suppress melanin production, lightening the skin color.
- Skin Thickening: It improves skin quality, preventing the underlying dark tissues from reflecting to the surface.
Differences Between Under-Eye Light Filler and Mesotherapy
Light Filler and Under-Eye Mesotherapy, two procedures most frequently confused by our patients, are actually complementary treatments serving different purposes.
PermanenceAverage 12-18 months.Average 6-12 months after treatment (Maintenance required).
| Features | Under-Eye Light Filler | Under-Eye Mesotherapy |
|---|---|---|
| Main Purpose | To fill in volume loss (hollowness) and eliminate shadowing. | To improve skin quality, brighten skin tone and repair fine lines. |
| Ingredients | Cross-linked (volumizing) Hyaluronic Acid. | Uncross-linked (fluid) Hyaluronic Acid, Vitamins, Peptides. |
| Effect Duration | Results are seen immediately. | The effect is seen cumulatively as the sessions progress. |
| Application Area | Under-eye hollow (Tear Trough) and bone area. | Entire eye area (lower and upper eyelids, crow’s feet). |
Who Can Under-Eye Mesotherapy?
This procedure is suitable for adult individuals who experience signs of aging or fatigue around the eyes and are in good general health. People who experience the following complaints are ideal candidates:
- Those who have dark circles and puffiness under their eyes.
- Those who have fine lines (dehydration lines) and loss of elasticity around their eyes.
- Those who experience puffiness (edema) under their eyes in the mornings.
- Those whose skin around the eyes appears dull, dry, and lifeless.
- Those who are genetically predisposed to pigmentation around the eyes.
Application Process and Session Planning
At Izmir Private Demiderm Polyclinic, the under-eye mesotherapy process is carried out in the following stages:
1. Examination and Analysis: The source of the problem (pigmentation, vascular, structural?) is determined.
2. Preparation: The area is cleaned and an anesthetic cream is applied for a comfortable procedure (wait approximately 15-20 minutes).
3. Injection: Using very fine-tipped (30G or 32G/34G) nano-needles, the product is injected into the dermis layer using the micro-papule technique or napaj technique. The procedure takes approximately 10-15 minutes.
4. End: A soothing cream is applied, and the patient returns to their daily life.
Reducing Fine Lines and Wrinkles with Under-Eye Mesotherapy
The first wrinkles around the eyes are usually caused by “dehydration” rather than facial expressions. The free hyaluronic acid in mesotherapy provides intense hydration to the skin, filling in these lines (hydro-filling). In addition, biomimetic peptides help soften lines caused by facial expressions (crow’s feet) by modulating acetylcholine release.
The Effect of Mesotherapy in Reducing Under-Eye Bags
Under-eye bags are caused by two reasons: fat herniation or edema (water retention). If the problem is fat herniation, the solution is usually surgical (blepharoplasty). However, if the problem is edema due to circulatory disorders and insufficient lymphatic drainage, mesotherapy is quite effective. The ingredients, such as artichoke extract, caffeine, and organic silicon, accelerate lymphatic circulation, helping to eliminate accumulated fluid and reduce the appearance of bags under the eyes.
Vitamin and Peptide Ingredients Used in the Application
The cocktails used are enriched according to the needs of the eye area:
- Hyaluronic Acid: Moisturizing and increased elasticity.
- Vitamin C: Antioxidant protection, collagen synthesis and brightening.
- Vitamin A (Retinol): Cell renewal and skin thickening.
- Vitamin E: Protection against free radicals.
- Peptides (Eye Area Peptides): Increased lymphatic drainage, tightening and Botox-like effect.
- Amino Acids: Building blocks for protein synthesis.
- Antioxidants (Glutathione etc.): Detoxifying effect and brightening.
How Many Sessions of Under-Eye Mesotherapy Are Needed?
Mesotherapy is a treatment that shows a cumulative effect. A miraculous change should not be expected in a single session. Generally, depending on the severity of the problem, courses of 3 to 6 sessions are recommended at 2-week intervals. After the course is completed, single-session reminder (maintenance) applications are recommended every 3-6 months to maintain the results.
Pre-Procedure Preparation and Important Considerations
- Discontinuing blood-thinning medications (under doctor’s supervision), green tea, vitamin E, and Omega-3 supplements 3-5 days before the procedure reduces the risk of bruising.
- Alcohol should not be consumed on the day of the procedure.
- If there is an active infection around the eyes (sty, conjunctivitis, etc.), the procedure will be postponed.
Recovery Process After Under-Eye Mesotherapy
This procedure is one that “does not affect social life.” Small bumps (papules) may be seen at the needle insertion sites after the procedure; these usually disappear within a few hours, at most within 24 hours. Since the area around the eyes is rich in blood vessels, small bruises (ecchymosis) may occur; these bruises can be covered with makeup and will disappear within 3-5 days. If edema occurs, applying a cold compress is soothing.
Mesotherapy Protocols That Improve Skin Quality Around the Eyes
At Izmir Private Demiderm Polyclinic, since each patient’s needs around the eyes are different, instead of a single standard product, a “personalized cocktail” or specific products aimed at a particular purpose (spots, bags, wrinkles) are preferred. Combinations with products containing Salmon DNA (Polynucleotides) are made to maximize cellular repair in order to improve skin quality.
Makeup and Return to Daily Routine Time
Immediately after the application, the patient can walk out of our clinic. To prevent the risk of infection, it is recommended not to apply eye makeup and not to get water on the area for the first 24 hours. Concealer or other cosmetic products can be used from the next day, and the normal skincare routine can be resumed.
How Long Does Under-Eye Mesotherapy Last?
The duration of mesotherapy varies depending on the person’s age, skin type, lifestyle (smoking, sleep patterns), and the quality of the product used. On average, the effects last between 6 months and 1 year after a full course of treatment. However, since the area around the eyes is constantly making facial expressions and continues to age, regular care and maintenance sessions are necessary.
Factors Causing Under-Eye Dark Circles and Mesotherapy Solutions
EyeUnder-eye dark circles are multifactorial:
- Genetics: Family predisposition (Tone lightens with mesotherapy).
- Anatomy: Sunken eye structure (Combined with light filler).
- Lifestyle: Lack of sleep, stress, screen use (Mesotherapy regulates circulation).
- Allergy: Pigmentation due to eye rubbing in atopic individuals (Mesotherapy repairs the barrier).
Is Under-Eye Mesotherapy Safe? Possible Side Effects
When performed by specialist physicians, under sterile conditions, and with CE certified products, it is a very safe procedure. Possible side effects are temporary and include: Mild redness, edema, bruising, and tenderness. Serious complications (infection, granuloma) may occur in applications performed by unqualified hands.
A Vibrant and Bright Appearance with Under-Eye Mesotherapy
The most noticeable result of the treatment is the “brightening” effect. With the regulation of circulation and the hydration of the skin, that tired, gray, and dull expression around the eyes is replaced by a fresher, rested, and energetic look. This positively affects the entire facial expression.
Under-Eye Mesotherapy Price Range and Influencing Factors
Pricing varies depending on the brand and content of the mesotherapy product used, the number of sessions to be applied, and the doctor’s plan. Due to Ministry of Health regulations, it is not appropriate to provide price information on the website. For a personalized treatment plan and price information, you need to visit our clinic for an examination.
When Will Under-Eye Mesotherapy Results Be Seen?
A hydration and brightness effect is felt in the skin from the first session. However, structural changes such as the reduction of dark circles and the smoothing of fine lines usually become noticeable after the 2nd or 3rd session. Mesotherapy is a process that requires patience but yields natural and healthy results.
Other Procedures That Can Be Combined with Under-Eye Mesotherapy
A multimodal approach gives the best results in rejuvenation of the eye area:
- Botox: To reduce crow’s feet.
- Light Filler: To fill in hollows.
- Laser Treatments: To improve skin quality and remove pigmentation.
- Dermapen: To trigger skin renewal.
These procedures can be planned together with mesotherapy within the schedule deemed appropriate by the physician.
Under-Eye Mesotherapy or Filler? Which is More Suitable?
If your main problem is “hollowing” and volume loss under the eyes, the primary choice should be Under-Eye Light Filler. However, if your problem is “discoloration” (bruising), “thinning skin,” “wrinkles,” or “swelling bags,” mesotherapy is a more appropriate option. Often, the best results are achieved by combining both procedures (such as improving skin quality first and then adding fillers).
Suitable Age Range for Under-Eye Mesotherapy
There is no definite lower or upper age limit for mesotherapy. An individual in their 20s with genetic bruising, as well as an individual in their 50s with wrinkles, can benefit from this procedure. The important thing is to correctly identify the need.
The Role of Hyaluronic Acid in Mesotherapy Contents
The hyaluronic acid (HA) used in under-eye mesotherapy is not cross-linked (for volume enhancement) like in fillers. Here, HA is in a “free” form and its primary function is to retain water. By replenishing the skin’s moisture reserves, it ensures healthier cell function, supports the extracellular matrix (intercellular environment), and increases skin elasticity.
Effective Treatment Option for Dark Under-Eye Circles: Mesotherapy
Dark circles (“Panda Eye” appearance) can affect a person’s social life and self-confidence. Mesotherapy lightens the color of the area by suppressing the melanin pigment that creates this darkness and accelerating blood circulation. With regular sessions, it is possible to achieve a more natural and healthy appearance around the eyes, reducing the need for concealer.
Under-Eye Mesotherapy and Environmental Factors in Izmir
Izmir is a city with many sunny days. The sun (UV rays) is the most important factor that accelerates collagen breakdown and increases pigmentation in the thin skin around the eyes. Patients living in Izmir should pay extra attention to sun protection (using sunglasses and SPF) while strengthening their skin with mesotherapy, as this will increase the success and permanence of the treatment. As Private Demiderm Polyclinic, we offer you the most suitable protection and treatment protocols, taking into account the climatic conditions of the region.
The content on this page is for informational purposes only. It does not constitute diagnosis or treatment. Eye area aesthetics and mesotherapy applications are medical procedures that should be planned individually for each patient.