Izmir Mesotherapy

Mesotherapy Applications in Izmir

What is Mesotherapy?

Mesotherapy, literally meaning “middle layer treatment,” is a method developed in 1952 by the French doctor Dr. Michel Pistor. It involves the micro-injection of pharmacological and homeopathic agents, vitamins, minerals, amino acids, and enzymes in special mixtures (cocktails) into the middle layer of the skin (mesoderm).

In traditional drug treatments (oral pills or intravenous medications), active substances are distributed throughout the body and may lose some of their effectiveness by being metabolized before reaching the target organ. The fundamental philosophy of mesotherapy is the principle of “A small amount, infrequently, and in the right place” (Peu, rarement et au bon endroit). In this way, medications are delivered directly to the problematic area (hair follicle, under the wrinkle, or cellulite tissue) without entering the systemic circulation, ensuring maximum bioavailability.

How Does Mesotherapy Work?

The therapeutic effect of mesotherapy is based on two main mechanisms:

• Pharmacological Effect: This is the biological effect of the active substances in the injected cocktail. For example, hyaluronic acid moisturizes the skin, caffeine breaks down fat cells, and biotin nourishes the hair follicle.

Physical (Reflex) Effect: Hundreds of micro-traumas created in the skin during the needling process trigger the skin’s healing mechanism. To repair these micro-damages, the body sends growth factors to the area, increases blood circulation, and initiates collagen-elastin synthesis. This allows the tissue to regenerate itself.

Mesotherapy Treatment Process and Application Stages

At Izmir Private Demiderm Polyclinic, mesotherapy applications are performed under the control of a physician, ensuring full compliance with the sterilization chain:

1. Consultation and Analysis: The patient’s complaints (hair loss, skin aging, blemishes, etc.) are listened to, their medical history is inquired about, and a skin analysis is performed. A personalized cocktail content is determined.

2. Preparation: The application area is cleaned with antiseptic solutions. To increase comfort, a local anesthetic cream is applied 20-30 minutes before the procedure.

3. Application: Using very fine-tipped (30G or 32G/33G) mesotherapy needles or mechanical guns (mesoguns), the prepared mixture is injected into the skin to a depth of 1-4 mm. The application technique (napaj, dot technique, or papule technique) varies depending on the type of problem.

4. Finishing: After the procedure, soothing masks or creams are applied to the skin.

Which Skin and Hair Problems Can Mesotherapy Be Used For?

Mesotherapy has a very wide range of indications:

• Face: Wrinkles, sagging, dullness, dehydration, acne scars, dark circles under the eyes.
• Hair: Androgenetic alopecia (male pattern baldness), telogen effluvium, hair thinning, dandruff.
• Body: Cellulite, localized fat, stretch mark (stria) treatment, hand rejuvenation.
• Spots: Sun spots, melasma, age spots.

Who is Mesotherapy Suitable For?

It is suitable for women and men who are 18 years of age or older and in good general health. However, it is not applied in the following cases (Contraindications):

• Individuals during pregnancy and breastfeeding.
• Those using blood thinners or those with clotting disorders.
• Those undergoing active cancer treatment.
• Patients with uncontrolled diabetes.
• Those with active infections (herpes, eczema) in the application area.
• Those allergic to the ingredients.

Mesotherapy Ingredients: Vitamins, Minerals and Peptides

Mesotherapy cocktails are prepared “customized”. The most commonly used components are:

Facial Mesotherapy (Mesolift) with Skin Rejuvenating Effects

Facial mesotherapy is one of the most powerful weapons against the signs of aging on the skin. Also known as “Mesolift,” this procedure restores the moisture and vitality the skin has lost. It smooths fine wrinkles and makes the skin look firmer and brighter. It creates a “Skin Detox” effect, especially in people who smoke, are stressed, and have tired skin, offering a brighter appearance.

Body Mesotherapy: Regional Slimming and Cellulite Treatment

Mesotherapy is effective in treating stubborn fat deposits (double chin, abdomen, hips) and cellulite that persist despite diet and exercise. Lipolytic (fat-breaking) and circulation-regulating agents make the membrane of fat cells permeable, facilitating fat removal and accelerating lymphatic circulation, reducing the appearance of orange peel skin.

Hair Mesotherapy: Solution to Hair Loss

This involves injecting vitamins and minerals needed by hair follicles directly into the scalp. It improves blood circulation, nourishing the hair follicles. It stops hair loss, thickens the hair shaft, and stimulates dormant follicles to promote new hair growth. It is particularly successful in seasonal hair loss and in the early stages of genetic hair loss.

Skin Tone Equalization with Spot Mesotherapy

This involves injecting substances such as Vitamin C, Glutathione, and Tranexamic Acid, which suppress melanin production (tyrosinase inhibitors), under the spot. It is much more effective than superficial creams because it targets the source of the spot. When combined with other methods (laser, etc.) in the treatment of sun spots and melasma, the success rate increases.

Anti-Aging Mesotherapy Protocols

In anti-aging protocols, the goal is to increase the fibroblast activity of the skin. Skin elasticity is increased and sagging is corrected with cocktails containing salmon DNA, stem cell extracts, and high levels of hyaluronic acid. These protocols aim to reverse the biological age of the skin.

How Many Mesotherapy Sessions Are Needed? Session Intervals

Mesotherapy is a treatment that shows a cumulative effect; miracles are not expected in a single session.

Face: Usually 3-6 sessions with 2-3 week intervals.

Hair: 6-10 sessions with 1-2 week intervals.

Body/Cellulite: 8-12 sessions with 1 week intervals.

After the course is completed, “booster” (maintenance) doses are recommended every 3-6 months to maintain the results.

Recovery Process After Mesotherapy

The procedure is classified as “lunchtime aesthetics”; the patient can immediately return to their daily life.

First 24 Hours: There may be slight redness, swelling, and pinpoint marks at the needle insertion sites.

Bruising: Minor bruising (ecchymosis) may occur in sensitive skin or in those using blood thinners; these usually disappear in 3-5 days.

Swelling: Mild swelling may occur, especially around the eyes.

Post-Mesotherapy Care Recommendations

• For the first 24 hours, do not apply water or makeup to the treatment area.
• Do not wash your hair for the first 24 hours after hair mesotherapy.
• Avoid sweating activities such as Turkish baths, saunas, swimming pools, and strenuous sports on the day of the procedure.
• Sun protection (high SPF) is essential to prevent the formation of blemishes.
• Drinking plenty of water increases toxin elimination and the effect of hyaluronic acid.

Duration of Mesotherapy Effects

The effect of mesotherapy is not permanent, as the aging process and metabolic activities continue. However, with regular courses and maintenance sessions, the improved state can be maintained for years. The duration of the effect varies depending on the person’s age, skin type, smoking habits, and dietary habits.

Mesotherapy Side Effects and Safety Information

When performed by specialist physicians, under sterile conditions, and with approved products, it is a very safe procedure. The risk of systemic side effects (the drug entering the bloodstream and affecting other organs) is very low. Possible side effects are local: redness, bruising, edema, itching, and rarely allergic reactions.

Does Mesotherapy Hurt? Comfort and Use of Local Anesthesia

Mesotherapy needles are very thin (even thinner than an insulin needle). The pain felt during the procedure is usually at the level of a “mosquito bite”. Thanks to the strong local anesthetic creams applied before the procedure, pain is minimized and a comfortable process is ensured.

Is Mesotherapy Applied During Pregnancy?

Due to hormonal changes during pregnancy and breastfeeding, and the risk (although low) of injected substances passing to the baby, mesotherapy is not medically recommended and is considered unethical.

Differences Between Mesotherapy, Fillers, and Botox

Botox: Relaxes muscles and smooths dynamic wrinkles.

Filler: Addresses volume loss and fills deep depressions.

Mesotherapy: Improves skin quality, nourishes, revitalizes, and provides overall improvement. It does not add volume or freeze muscles. These three procedures are not alternatives to each other, but rather complementary.

Combined Treatments: Mesotherapy + Dermapen / PRP

Mesotherapy creates a wonderful synergy with other methods:

With Dermapen: Absorption of mesotherapy serums through channels opened in the skin is increased by up to 300%.

With PRP: The combination of growth factors and vitamins maximizes cell regeneration.

Effects of Mesotherapy on Skin Hydration

Skin moisture is critical for barrier function and elasticity. Hyaluronic Acid used in mesotherapy has a water-holding capacity of 1000 times its own weight. When injected into the skin, it attracts and traps water molecules. This moisturizes the skin “from within,” plumps up fine lines, and smooths the skin surface.

When Will Mesotherapy Results Be Seen?

A brightness and vitality (Cinderella effect) is noticeable on the skin a few days after the first session. However, the real structural improvement becomes noticeable after the 3rd or 4th session, when collagen production increases. In hair treatment, stopping hair loss may take 3-4 sessions, and new hair growth may take 3-4 months.

Mesotherapy Prices and Determining Factors

Pricing varies depending on the brand of the product used, the richness of its content (whether it contains peptides, salmon DNA, etc.), the size of the treatment area, and the number of sessions. Very cheap products with weak content or unapproved products can be found on the market. For your health, it is important to choose clinics that use FDA-approved and CE-certified products. According to Ministry of Health regulations, providing price information via the website is not appropriate.

Mesotherapy Planning According to Age and Skin Type

20-30 Years: For preventative purposes, moisture and vitamin support (Vitamin Detox).

30-45 Years: Treatment of early signs of aging, fine lines, and blemishes (Hyaluronic Acid + Peptides).

Ages 45+: Intensive repair, tightening, and lifting effect (Salmon DNA, DMAE, Collagen injections).

Things to Know Before Mesotherapy

Mesotherapy is not a “magic wand,” but a scientific treatment process. Patience, regular session follow-up, and adherence to the doctor’s recommendations are necessary for success. The aim of the treatment is not to make you look like someone else, but to reveal the healthiest and most vibrant version of your skin. Smoking, poor diet, and irregular sleep are factors that negatively affect the success of the treatment.