How does the Enzyme Peeling (Cosmelan / Dermamelan) treatment protocol for blemishes work, and why is it different from regular peels?

Update date: 11 June 2026

While conventional chemical peels attempt to remove blemished cells by exfoliating the skin, Enzyme Peeling (Cosmelan/Dermamelan) blocks the skin’s blemish-producing mechanism at the cellular level. By suppressing the “Tyrosinase” enzyme, which causes blemish formation, it prevents melanocyte cells from producing excessive melanin (color pigment). The protocol begins with a mask (a layer with a soup-like consistency) applied by a physician in the clinic; this mask remains on the skin for 8-12 hours. This is followed by the use of special maintenance creams at home for months to support the process. It is a treatment system with the highest success rate for pregnancy spots (melasma) and sun spots, suppressing rather than exfoliating.

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